Early Symptoms Of Uremia? Watch Out For These Signs

Some patients with kidney disease will be surprised when they find out that they have uremia: they can eat and drink normally, and they don’t feel any discomfort. They just came to see a cold, so how did they find out that they have uremia?

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In fact, uremia will not be "fixed overnight"! Because our kidneys have a very strong compensatory function, early kidney disease generally does not have too many symptoms, so it is difficult to detect early kidney disease without careful physical examination, which leads many people without medical knowledge to ignore chronic kidney disease Of course, there are still some people who do not understand the early symptoms of uremia, and often treat some symptoms of uremia as diseases of other departments and delay treatment. Therefore, today I will talk about the early symptoms of uremia from a professional point of view, hoping to help you!

The vast majority of uremia patients do not have typical symptoms in the early stage. The more common discomfort is a little fatigue, and some people start to urinate more at night, especially in the second half of the night. Most of this phenomenon of nocturia is due to the decline of kidney function, the toxins produced during the day cannot be excreted, and they have to use the night to "work overtime". So sometimes nocturia is the earliest symptom of renal dysfunction. There are also some hypertensive patients whose antihypertensive treatment was very effective, but suddenly and inexplicably ineffective recently. In this case, we must be careful because the kidney function cannot compensate for and maintain the current blood pressure. There are also some female patients who have unexplained anemia or increased menstrual flow. Be careful because of kidney problems, because human hematopoietic function mainly depends on the secretion of a kind of erythrogen by the kidney. Once the kidney function is abnormal, the secretion of this hormone secretion will be significantly reduced.

How to detect uremia early?

The following 6 symptoms may be associated with early uremia.

01 Gastrointestinal symptoms

Some patients often suffer from nausea and vomiting when brushing their teeth in the morning. This phenomenon often does not last long and can be improved after diverting attention. In fact, nausea, vomiting, and loss of appetite are the early and most common manifestations of uremia. Don't think that nausea and vomiting are all stomach problems. Taking a large amount of stomach medicine will delay the condition.

02 Cardiovascular system disease

Kidney disease can cause high blood pressure, and high blood pressure can damage the kidneys. Renal hypertension is often the earliest symptom of renal function deterioration in chronic kidney disease. Some people think that it is normal for their parents to have high blood pressure and their own high blood pressure is a genetic phenomenon. Strictly speaking, the cause of hypertension that occurs before the age of 40 must be carefully searched for, such as secondary hypertension caused by chronic nephritis and primary aldosteronism. It can prevent the progression of the disease, and can also prevent heart hypertrophy and even heart failure.

03 Blood system symptoms

Uremic patients may experience increased menstrual flow, epistaxis, bleeding gums, skin ecchymosis, pale complexion, fatigue, etc. due to elevated levels of toxins in the body. Abnormal blood coagulation, anemia, thrombocytopenia, etc., will be found in the hospital for examination.

How can you become anemic if your kidneys are not good? It turns out that the kidneys secrete a hematopoietic substance—erythropoietin. When the kidney function declines, the secretion of this substance will decrease, red blood cell production will be impaired, and anemia will gradually appear, which is called renal anemia. Generally speaking, renal anemia occurs when the glomerular filtration rate is less than 60ml/min.

04 Water and electrolyte imbalance

Early edema is mainly manifested as eyelid edema and/or pitting edema of both lower limbs. In the late stage, body cavity effusions (pleural and peritoneal effusions, chest tightness, shortness of breath, or abdominal distension may occur; if edema is found and urine output is significantly reduced, you must seek medical advice in time), Be careful with elevated blood potassium, severe hyperkalemia can be life-threatening. It is worth mentioning that many patients with kidney disease are using renin-angiotensin inhibitor drugs to control high blood pressure and proteinuria. These drugs can easily cause hyperkalemia, so unexplained chest tightness, fatigue, Poor diet, pay attention to check blood potassium.

05 Increased nocturia

Normal adults generally do not urinate at night, if they get up 2-3 times or more habitually every night, and the urine output at night is more than 1/3 of the total urine output in 24 hours, then there may be a problem with the kidney's concentrating function, and you should go to the hospital immediately Check your kidney function.

06 Skeletal system

Patients with uremia often lack bone-regulating hormones in their bodies and are prone to osteoporosis, osteomalacia, or osteitis fibrosa, manifested as bone pain all over the body, such as knee pain when climbing stairs, and heel pain after walking for a long time. A fracture occurs.

In addition, uremia covers all systems of the body, and may also have symptoms such as bad breath, itchy skin, tetany, sleep disturbance, etc. If you suspect that you have uremia, blood routine, urine routine, kidney function, double kidney B-ultrasound, to rule out kidney disease it's actually really easy. For high-risk patients such as diabetes, high blood pressure, gout, and obesity, regular physical examinations should be given for early intervention.

Why eating Cistanche is good for kidney disease

Cistanche is a type of herb commonly used in traditional Chinese medicine. It has been suggested to have a protective effect on kidney function and may have potential benefits for those with kidney disease. One study published in the Journal of Ethnopharmacology found that cistanche had a renal protective effect in rats with kidney damage caused by diabetes. The study showed that cistanche helped to reduce the levels of creatinine and blood urea nitrogen (BUN), which are markers of kidney function. Additionally, it was found that cistanche helped to prevent oxidative damage and inflammation in the kidneys. Another study published in the Journal of Medicinal Food looked at the protective effects of cistanche on kidney function in rats with liver damage. The study found that cistanche helped to improve kidney function by reducing oxidative stress, inflammation, and fibrogenesis. Overall, while more research is needed in humans, studies suggest that cistanche has the potential as a natural supplement to support kidney function. 

Reference:

- Chinese Herbal Medicine for the Management of Chronic Kidney Disease: An Overview of Systematic Reviews; Yu-Feng Qin, Jiang-Hua Chen, Ming-Hua Guo, Dan-Dan Liu, Ling-Li Zhang; Evidence-Based Complementary and Alternative Medicine; Volume 2018, Article ID 8094231, 14 pages. 

- Curative effect of Cistanche tubulosa aqueous extract against diabetic renal damage and the underlying mechanisms; Qian L, Ma X, Jiang N, Wang Y, Jiang Y, Zhou Y, Xu R; J Ethnopharmacol. 2016 Jan 11;177:113-9.